Prescriptions for weight reduction medicines have skyrocketed in recent times. By the top of 2024, the market valuation is predicted to develop to a whopping $21.09 billion.1 In the present day, one of the vital well-liked choices are GLP-1 agonist medicine which can be offered below two names, Ozempic and Wegovy. Each are from the Novo Nordisk drug firm — Ozempic is offered as a diabetes drug, whereas higher-dose Wegovy is permitted for weight reduction.2
The recognition of GLP-1 agonist medicine for weight administration has boomed in recent times, and it reveals — fairly actually. In the present day, extra customers are combating a aspect impact dubbed the “Ozempic face”3 — a situation that happens when an individual loses an excessive amount of facial fats, resulting in a hollowed, gaunt look, because of taking these medicine.4
How Do GLP-1 Mimetics Work?
Glucagon-like peptide-1 (GLP-1) receptor agonists work by boosting the hormone GLP-1. The drug was first permitted in 2017 to handle blood sugar ranges in diabetics, and, in 2021, the FDA permitted Wegovy to handle weight problems.5 Semaglutide is the energetic ingredient in each.
Your physique naturally makes GLP-1 within the small intestines,6 and its main operate is to decelerate digestion, enhance satiety, block glucagon secretion (a hormone used to regulate blood sugar ranges) and set off the pancreas to launch insulin.7
When used as an injectable remedy, semaglutide mimics the hormone, so the remedy binds to the receptor and triggers the identical results. In consequence, the passage of meals by means of your abdomen slows down, making you’re feeling fuller longer. In line with an article printed in El Pais:8
“Ozempic offers the sensation of being without end full, so that you could say goodbye to snacking, and be happy with smaller parts of meals. Quickly, although, nausea, vomiting, diarrhea or constipation can seem. After a number of months, the ‘Ozempic face’ could present up within the type of prematurely aged pores and skin.”
Trims Inches Off the Waist, however Provides Years to Your Face
Whenever you take semaglutide, it doesn’t simply trigger you to shed fats from particular physique drawback areas; it may additionally deplete your facial fats leading to misplaced quantity.9 When your physique slims down very quickly, the elasticity of your pores and skin, particularly on the face, may be severely affected.10 The end result — sunken eyes, fantastic traces, indents and wrinkles, drooping cheeks, sagging pores and skin (together with below the chin) and modifications within the measurement of the lips and chin.11,12
Semaglutide has helped some to slim down, however at the price of ageing pores and skin, notably in your face. In a Forbes article, Mojgan Hosseinipour, D.O., a board-certified dermatologist, says, “Subcutaneous facial fats offers structural assist; with quantity loss, there’s an accelerated aged look of the face with noticeable traces and wrinkles.”13
These bodily results could also be extra obvious in individuals with skinny faces who’ve skilled drastic weight reduction. Aesthetic physician, Mar Mira, explains in an El Pais article:14
“[I]n chubby or overweight sufferers, weight reduction doesn’t often lead to vital facial skeletonization.
Nevertheless, shadows beneath the cheeks could also be accentuated by reabsorption of fats compartments, and facial flaccidity can grow to be extra pronounced across the jowls and jaw line as a result of lack of temporal and preauricular fats compartments, that are often the primary to be reabsorbed through the growing old course of.”
Skincare Firms Are Taking Benefit of the Ozempic Face
A 2023 research15 notes how the rising variety of individuals with Ozempic face are impacting the sphere of cosmetic surgery. In line with the researchers, “As the recognition of Ozempic grows, facial plastic surgeons should pay attention to each the impression on facial look and perioperative concerns.”
The research additionally mentions that strategies like dermal fillers, pores and skin tightening methods and surgical procedure could also be wanted to handle extra pores and skin and restore a affected person’s facial quantity. This has prompted some skincare corporations to arrange for the surge of people that could need to handle the growing old results attributable to Ozempic.
In a Bloomberg article, skincare agency Galderma’s CEO Flemming Ornskov stated their Sculptra pores and skin therapy, which boosts collagen manufacturing, and different fillers may help “restore” sufferers’ facial options.16
Some physicians have additionally commented on the modifications they see amongst individuals who took Ozempic. In an article printed in Attract, Julius Few, MD, a Chicago-based, board-certified plastic surgeon, says, “I’ve seen various sufferers for facelifts who’re on Ozempic, and the best way their tissue behaves just isn’t the identical. The pores and skin has extra of a doughy consistency.”
What’s extra, Few feedback that individuals of their 20s and 30s are actually going past fillers — they’re additionally inquiring about procedures like facelifts, that are often tailor-made for these over 50 years outdated.17
Ozempic’s Aspect Results Can Be Alarming
However except for the facial modifications, Ozempic and different GLP-1 medicine can produce other extra disturbing unintended effects. A Lady’s World journal article,18 for instance, demonstrated the drastic weight reduction that Sharon Osbourne underwent after taking Ozempic. The 70-year-old TV character misplaced a whopping 42 kilos.
The change to her facial look is noticeable and has grow to be one of the vital startling examples of the Ozempic face. Nevertheless, the article quotes an interview with Piers Morgan that Osbourne did again in September 2023, the place she additional shared her disagreeable expertise after utilizing the drug:20
“At first, I imply, you’re feeling nauseous. You don’t throw up bodily, however you’ve bought that feeling. It was about two, three weeks the place I felt nauseous the entire time. You get very thirsty and also you don’t need to eat. That’s it.
You possibly can’t keep on it without end. I misplaced 42 kilos now and it’s simply sufficient. I didn’t truly need to go this skinny, however it simply occurred, and I’ll in all probability put all of it on once more quickly.”
Actuality TV character Scott Disick has additionally spoken up about his dramatic weight reduction courtesy of Ozempic, and that he’s “in search of assist” to get off the drug after followers raised their considerations over his alarming transformation, together with his gaunt face and sunken eyes. He has stopped taking the drug and is now working with a nutritionist to handle his weight.21
Others who’ve been prescribed GLP-1 agonist medicine to handle different well being points have additionally spoken up in regards to the nasty results of Ozempic. In a In the present day article,23 hospital employee Jeannine DellaVecchia stated she took the drug to “deal with signs associated to insulin resistance attributable to congenital adrenal hyperplasia and polycystic ovary syndrome.”
Regardless of dropping 30 kilos, she opted to cease utilizing Ozempic as a result of the unintended effects have been “simply an excessive amount of.” Except for the noticeable facial modifications, DellaVecchia additionally struggled with urge for food loss, nausea and vomiting.24
Utilizing Weight Loss Medication Can Have Disastrous Penalties on Your Intestine Well being
The issue with GLP-1 agonists is that in the event that they trigger meals passage to sluggish an excessive amount of, it may result in well being points, notably gastrointestinal issues. One 2023 research26 famous that people who find themselves taking GLP-1 agonists had an elevated threat of pancreatitis, bowel obstruction and gastroparesis (abdomen paralysis).
A research27 utilizing knowledge from Eudravigilance, Europe’s system for analyzing adversarial reactions to medicines, additionally discovered that apart from gastrointestinal considerations, metabolic, dietary, eye, renal, urinary and cardiac issues additionally occurred in individuals who took semaglutide.
One research notes28 the results on the kidneys happen extra typically in individuals who even have adversarial gastrointestinal issues when taking the drug. And, as with DellaVecchia’s expertise famous above, many individuals developed “cyclic-vomiting syndrome” — a situation the place an individual vomits a number of instances in a day. In line with a CNN article:29
“Emily Wright, 38, a instructor in Toronto, began taking Ozempic in 2018. Over a yr, she stated, she misplaced 80 kilos, which she’s been capable of preserve off. However Wright stated she now vomits so ceaselessly that she needed to take a go away of absence from her job. ‘I’ve nearly been off Ozempic for a yr, however I’m nonetheless not again to my regular,’ Wright stated.”
As an alternative of Ozempic, Improve Your GLP-1 Naturally With Akkermansia
Taking medicines to drop extra pounds is one method to endanger your well being. Ozempic was designed as a long-term drug. In different phrases, to take care of your weight reduction, you have to keep on the drug. One research30 discovered {that a} yr after stopping semaglutide, contributors gained again two-thirds of the burden they misplaced — a situation known as the “Ozempic rebound.”31
As an alternative of counting on GLP-1 agonists, take into account colonizing your intestine with Akkermansia muciniphila to spice up your GLP-1 ranges naturally. Akkermansia is a sort of bacterium that naturally secretes a GLP-1-inducing protein, which raises systemic ranges of GLP-1. Analysis32 confirms its potential to enhance glucose homeostasis and ameliorate metabolic illness by means of this mechanism. In line with the researchers:33
“A. muciniphila will increase thermogenesis and glucagon-like peptide-1 (GLP-1) secretion … by induction of uncoupling protein 1 in brown adipose tissue and systemic GLP-1 secretion … [An] 84 kDa protein, named P9 … is secreted by A. muciniphila. [We] present that purified P9 alone is adequate to induce GLP-1 secretion …”
Learn how to Restructure Your Microbiome
Akkermansia, extremely useful micro organism in your massive gut, performs a vital function in sustaining intestine well being and will represent about 10% of the intestine microbiome. Nevertheless, it’s absent in lots of people, seemingly as a consequence of insufficient mitochondrial operate and resultant oxygen leakage within the intestine.
Consuming meals that assist Akkermansia, resembling polyphenol-rich fruit, and different useful micro organism, and avoiding meals like linoleic acid — present in vegetable and seed oils in most processed meals — that destroy these micro organism, will assist to restructure your microbiome in a optimistic method. You may also use an Akkermansia probiotic complement.
One of many causes Akkermansia is so vital is as a result of it produces mucin, a thick, protecting gel-like substance that traces numerous elements of the physique, together with the gastrointestinal tract. Mucin kinds a protecting barrier on the intestine lining, shielding the epithelial cells of the intestinal wall from mechanical injury, chemical irritation from abdomen acids and digestive enzymes, and pathogenic organisms like micro organism and viruses.
Mucin additionally helps the immune system by trapping potential pathogens and different international particles, that are then expelled from the physique by means of the digestive course of. It additionally incorporates antibodies and antimicrobial peptides that assist battle off infections.
Lastly, mucin serves as a meals supply for different useful intestine micro organism. This relationship is important for digestive well being, because the micro organism fed by Akkermansia support in digestion, produce important vitamins and assist keep an total steadiness of intestine flora.
Avoiding Linoleic Acid Can Assist With Weight Administration
The abundance of linoleic acid (LA) in our weight loss plan is another excuse why many are combating weight problems or are chubby. This omega-6 fats is present in seed oils like sunflower, soybean, rapeseed (canola), cottonseed, corn and safflower, and lowering your consumption may help assist a wholesome weight.
Be sure that to keep away from all processed meals, as these additionally comprise excessive quantities of LA, in addition to grain-fed hen and pork. Ideally, reduce your LA consumption all the way down to under 5 grams per day, which is near what our ancestors used to get earlier than power well being circumstances grew to become widespread.
LA is present in practically all ultraprocessed meals, quick meals and restaurant meals as nicely. This is the reason it’s finest to arrange nearly all of your meals at dwelling. For extra data on linoleic acid, learn my article “Linoleic Acid — The Most Damaging Ingredient in Your Weight-reduction plan.”
